Difference between revisions of "Phosphatase Subfamily TAB1"
From PhosphataseWiki
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* TAK1 <cite>Shibuya96</cite> | * TAK1 <cite>Shibuya96</cite> | ||
* MEKK1 <cite>Charlaftis14</cite>. TAB1 is ubiquitinated by MEKK1 PHD domain. | * MEKK1 <cite>Charlaftis14</cite>. TAB1 is ubiquitinated by MEKK1 PHD domain. | ||
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| + | Human TAB1 is modified with N-acetylglucosamine (O-GlcNAc) on a single site, Ser-395. The modification is induced by IL-1 and osmotic stress, known inducers of the TAK1 signalling cascade. However, the serine at position 395 is only found in vertebrates. | ||
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=== References === | === References === | ||
<biblio> | <biblio> | ||
Revision as of 22:50, 8 June 2015
Phosphatase Classification: Fold PPM (PP2C): Superfamily PPM (PP2C): Family PPM (PP2C): Subfamily TAB1
Evolution
Domain
Function
Human TAB1 interacts with:
- TRAF6 []
- p38 [1, 2, 3]. TAB1 functions as a scaffold protein in the activation of p38 [3]
- TAK1 [4]
- MEKK1 [5]. TAB1 is ubiquitinated by MEKK1 PHD domain.
Human TAB1 is modified with N-acetylglucosamine (O-GlcNAc) on a single site, Ser-395. The modification is induced by IL-1 and osmotic stress, known inducers of the TAK1 signalling cascade. However, the serine at position 395 is only found in vertebrates.
References
Error fetching PMID 25260751:
Error fetching PMID 12429732:
Error fetching PMID 25151490:
Error fetching PMID 8638164:
Error fetching PMID 23934659:
Error fetching PMID 12429732:
Error fetching PMID 25151490:
Error fetching PMID 8638164:
Error fetching PMID 23934659:
- Error fetching PMID 12429732:
- Error fetching PMID 25151490:
- Error fetching PMID 8638164:
- Error fetching PMID 25260751:
- Error fetching PMID 23934659:
