Difference between revisions of "Phosphatase Subfamily TAB1"
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=== Domain === | === Domain === | ||
| + | The TAB1 subfamily has a phosphatase domain of PPM fold. | ||
=== Function === | === Function === | ||
| − | |||
| − | + | ===== Human TAB1 is a pseudophosphatase but basal metazoa TAB1s are probably active ===== | |
| − | + | Human TAB1 is a pseudophosphatase. Several key residues required for dual metal-binding (D69N, D290E, D356E, N367D) and catalysis (H71Y) are substitued by other amino acids <cite>Conner06</cite>. However, not all of the substitutions are conserved in TAB1s. D69 is found in metazoa, such as sponge, nematostella and sea urchin; D290 is found in metazoa except chordates, such as sponge, nematostella and C. elegans; D356 is found in metazoa, such as sponge, nematostella and sea urchin; H71 is found in basal metazoa, such as nematostella and sponge. Thus, TAB1s in basal metazoa are probably active, though human TAB1 is inactive. | |
| − | + | ||
| − | + | ||
| − | Human TAB1 | + | ===== TAB1-TAK1 complex ===== |
| + | Human TAB1 associated with TAK1 <cite>Shibuya96</cite>. The association induces TAK1 autoactivation <cite>Scholz10</cite>. | ||
| + | * TRAF6 <cite></cite>. | ||
| + | * p38α <cite>Ge02, Zhu13, Lanna14</cite>. TAB1 functions as a scaffold protein in the activation of p38 <cite>Lanna14</cite>. The interaction between TAB1 and p38α is mediated by Pro-412 on TAB1 and a hydrophobic docking groove on p38α <cite>Zhou06</cite>. The Pro-412 of TAB1 does not localize in a conserved region, so it is hard to tell whether it is conserved. | ||
| + | |||
| + | * MEKK1 <cite>Charlaftis14</cite>. TAB1 is ubiquitinated by MEKK1 PHD domain. | ||
| + | Human TAB1 can be dephosphorylated at Ser-452, Ser-453, Ser-456, Ser-457 by TAK1 and p38 <cite>Wolf11</cite>. These sites are not found in invertebrates. | ||
| + | |||
=== References === | === References === | ||
<biblio> | <biblio> | ||
#Charlaftis14 pmid=25260751 | #Charlaftis14 pmid=25260751 | ||
| + | #Conner06 pmid=16879102 | ||
#Ge02 pmid=12429732 | #Ge02 pmid=12429732 | ||
#Lanna14 pmid=25151490 | #Lanna14 pmid=25151490 | ||
| + | #Scholz10 pmid=20538596 | ||
#Shibuya96 pmid=8638164 | #Shibuya96 pmid=8638164 | ||
| + | #Zhou06 pmid=16648477 | ||
#Zhu14 pmid=23934659 | #Zhu14 pmid=23934659 | ||
</biblio> | </biblio> | ||
Revision as of 15:25, 9 June 2015
Phosphatase Classification: Fold PPM (PP2C): Superfamily PPM (PP2C): Family PPM (PP2C): Subfamily TAB1
Evolution
Domain
The TAB1 subfamily has a phosphatase domain of PPM fold.
Function
Human TAB1 is a pseudophosphatase but basal metazoa TAB1s are probably active
Human TAB1 is a pseudophosphatase. Several key residues required for dual metal-binding (D69N, D290E, D356E, N367D) and catalysis (H71Y) are substitued by other amino acids [1]. However, not all of the substitutions are conserved in TAB1s. D69 is found in metazoa, such as sponge, nematostella and sea urchin; D290 is found in metazoa except chordates, such as sponge, nematostella and C. elegans; D356 is found in metazoa, such as sponge, nematostella and sea urchin; H71 is found in basal metazoa, such as nematostella and sponge. Thus, TAB1s in basal metazoa are probably active, though human TAB1 is inactive.
TAB1-TAK1 complex
Human TAB1 associated with TAK1 [2]. The association induces TAK1 autoactivation [3].
- TRAF6 [].
- p38α [4, 5, 6]. TAB1 functions as a scaffold protein in the activation of p38 [6]. The interaction between TAB1 and p38α is mediated by Pro-412 on TAB1 and a hydrophobic docking groove on p38α [7]. The Pro-412 of TAB1 does not localize in a conserved region, so it is hard to tell whether it is conserved.
- MEKK1 [8]. TAB1 is ubiquitinated by MEKK1 PHD domain.
Human TAB1 can be dephosphorylated at Ser-452, Ser-453, Ser-456, Ser-457 by TAK1 and p38 [9]. These sites are not found in invertebrates.
References
Error fetching PMID 16879102:
Error fetching PMID 12429732:
Error fetching PMID 25151490:
Error fetching PMID 20538596:
Error fetching PMID 8638164:
Error fetching PMID 16648477:
Error fetching PMID 23934659:
- Error fetching PMID 16879102:
- Error fetching PMID 8638164:
- Error fetching PMID 20538596:
- Error fetching PMID 12429732:
- Error fetching PMID 25151490:
- Error fetching PMID 16648477:
- Error fetching PMID 25260751:
- Error fetching PMID 23934659:
