Difference between revisions of "Phosphatase Subfamily TIMM50"
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Revision as of 05:30, 29 December 2014
Contents
Phosphatase Classification: FCP:TIMM50
Introduction
TIMM50 (or TIM50) is named after translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) [1] [2]. It is a subunit of the TIM23 complex that links protein translocation across the outer and inner mitochondrial membranes. It lacks the DxDx[T|V] motif at catalytic site.
Related Kinases
1) Raf. High throughput yeast two-hybrid assay show Raf kinase can interact with TIMM50, as well as FCP1. The paper also guessed Raf is the substrate of TIMM50 [3], but actually TIMM50 lacks the catalytic motif. (Note: Raf also interacts with FCP1 in the paper).
Evolutionary History
TIMM50 is conserved from yeast to human, while Raf is conserved from sponge to human.
Domain Combination
Catalytic activity
No.
Curation notes
References
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Error fetching PMID 12437925:
Error fetching PMID 16763150:
- Error fetching PMID 12437925:
- Error fetching PMID 16763150:
- Error fetching PMID 12620389:
Links
Human TIMM50 from NCBI Gene
