Difference between revisions of "Phosphatase Family SSU72"
From PhosphataseWiki
| Line 3: | Line 3: | ||
===Evolution=== | ===Evolution=== | ||
| − | SSU72 is found in most eukaryotes, but is lost in most excavates and some chromalveolates. It is usually present in one copy, but humans also have | + | SSU72 is found in most eukaryotes, but is lost in most excavates and some chromalveolates. It is usually present in one copy, but humans also have 8 SSU72 retrogenes of unknown function. |
===Domain Architecture=== | ===Domain Architecture=== | ||
Revision as of 18:20, 12 November 2016
Phosphatase Classification: Superfamily CC2: Family SSU72
Evolution
SSU72 is found in most eukaryotes, but is lost in most excavates and some chromalveolates. It is usually present in one copy, but humans also have 8 SSU72 retrogenes of unknown function.
Domain Architecture
SSU72 consist of just a phosphatase domain, with no N- or C-terminal extensions.
Function
The phosphatase activity of Ssu72 is important for Pol II transcription and termination and for gene looping. It catalyzes CTD Serine-5 dephosphorylation in association with the Pta1 component of the CPF complex. In yeast, Ssu72 is required for pre-mRNA 3’-end cleavage, but so far no evidence exists implicating mammalian Ssu72 in that processing [1] [2].
Reference
Error fetching PMID 15125841:
Error fetching PMID 20861839:
Error fetching PMID 20861839:
- Error fetching PMID 15125841:
- Error fetching PMID 20861839:
