Difference between revisions of "Phosphatase Subfamily PTEN"
From PhosphataseWiki
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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_PTEN|Family PTEN]]: [[Phosphatase_Subfamily_PTEN|Subfamily PTEN]] | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_PTEN|Family PTEN]]: [[Phosphatase_Subfamily_PTEN|Subfamily PTEN]] | ||
| − | This page is a stub. | + | ''This page is a stub - more information to follow.'' |
| + | |||
| + | PTEN subfamily is named after its single member in human, PTEN, which dephosphorylates phosphatidylinositol (3,4,5)-trisphosphate (PtdIns (3,4,5)P3 or PIP3). PTEN is one of the most commonly lost tumor suppressors in human cancer. | ||
===Evolution=== | ===Evolution=== | ||
| + | PTEN is found in almost all eukaryotes. | ||
===Domain Structure=== | ===Domain Structure=== | ||
| + | Most PTEN have a phosphatase domain followed by a C2 domain. Some homologs have PH (phospholipid-binding) or LIM domains, but these are not conserved. | ||
===Functions=== | ===Functions=== | ||
| + | PTEN is a critical negative regulator of PI3K signaling. | ||
===References=== | ===References=== | ||
<biblio> | <biblio> | ||
</biblio> | </biblio> | ||
Revision as of 06:58, 28 December 2014
Phosphatase Classification: Superfamily CC1: Family PTEN: Subfamily PTEN
This page is a stub - more information to follow.
PTEN subfamily is named after its single member in human, PTEN, which dephosphorylates phosphatidylinositol (3,4,5)-trisphosphate (PtdIns (3,4,5)P3 or PIP3). PTEN is one of the most commonly lost tumor suppressors in human cancer.
Evolution
PTEN is found in almost all eukaryotes.
Domain Structure
Most PTEN have a phosphatase domain followed by a C2 domain. Some homologs have PH (phospholipid-binding) or LIM domains, but these are not conserved.
Functions
PTEN is a critical negative regulator of PI3K signaling.
