Difference between revisions of "Phosphatase Subfamily UBLCP1"
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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Family_FCP|FCP]]: [[Phosphatase_Subfamily_UBLCP1|Subfamily UBLCP1]] | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Family_FCP|FCP]]: [[Phosphatase_Subfamily_UBLCP1|Subfamily UBLCP1]] | ||
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UBLCP1 is named after Ubiquitin-like domain containing CTD phosphatase 1. It has an accessary N-terminal domain, similar to ubiquitin. Its function is not well characterized, though in vitro assay showed phosphatase activity toward RNA polymerase II C-terminal domain <cite>clone</cite>. | UBLCP1 is named after Ubiquitin-like domain containing CTD phosphatase 1. It has an accessary N-terminal domain, similar to ubiquitin. Its function is not well characterized, though in vitro assay showed phosphatase activity toward RNA polymerase II C-terminal domain <cite>clone</cite>. | ||
Latest revision as of 05:35, 29 December 2014
Phosphatase Classification: FCP: Subfamily UBLCP1
UBLCP1 is named after Ubiquitin-like domain containing CTD phosphatase 1. It has an accessary N-terminal domain, similar to ubiquitin. Its function is not well characterized, though in vitro assay showed phosphatase activity toward RNA polymerase II C-terminal domain [1].
Evolution
It is conserved from Nematostella to human but lost in nematode. However, UBLCP1-like proteins can be found in plants.
Domain Structure
Related Kinases
See Phosphorylation of RNA polymerase II C-terminal domain.
Catalytic activity
It has a different catalytic motif from other subfamilies of FCP.
Curation notes
References
- Zheng H, Ji C, Gu S, Shi B, Wang J, Xie Y, and Mao Y. Cloning and characterization of a novel RNA polymerase II C-terminal domain phosphatase. Biochem Biophys Res Commun. 2005 Jun 17;331(4):1401-7. DOI:10.1016/j.bbrc.2005.04.065 |
Links
Human UBLCP1 from NCBI Gene
