Difference between revisions of "Phosphatase Subfamily CTDSPL2"
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Revision as of 01:02, 22 March 2017
Phosphatase Classification: FCP: CTDSPL2
CTDSPL2 (CTD small phosphatase like 2) is a poorly-studied RNA polymerase CTD phosphatase which is found in most eukaryotes.
Evolution
CTDSPL2 is found as a single copy gene in most eukaryotes. It is absent from all but a few basal fungi, and is also lost in Drosophilids. The human gene is called CTSDPL2, HSPC058, HSPC129, or SCP4
Domain Structure
Usually a C-terminal phosphatase domain with a relatively poorly conserved N-terminal extension
Catalytic activity
Human CTDSPL2 has experimentally-shown activity [1] and orthologs are also predicted to be active.
Functions
Human CTDSPL2 binds and dephosphorylates Smad1/5/8, and attenuates signaling through the BMP pathway [2]
Related Kinases
See Phosphorylation of RNA polymerase II C-terminal domain.
References
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- Error fetching PMID 17487459:
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Links
Human CTDSPL2 from NCBI Gene
