Difference between revisions of "Phosphatase Family RTR1"
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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_RTR1|Superfamily RTR1]]: [[Phosphatase_Family_RTR1|Family RTR1]] | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_RTR1|Superfamily RTR1]]: [[Phosphatase_Family_RTR1|Family RTR1]] | ||
| − | + | === Evolution === | |
| + | RTR1 is found in most of eukaryotes. It is absent from Monosiga and sponge genome, though it is perhaps due to the quality of genome assembly. It is single copy in human, sea urchin, fruit fly, ''C elegans''. However, two copies are found in yeast. | ||
| + | === Domain === | ||
| + | RTR1 has a conserved domain that carries out the phosphatase activity. Yeast RTR1 has a C-terminal region (CTR) that auto-inhibits the catalytic domain <cite>hsu14</cite>. Human RTR1 encoded by gene RPAP2 has a longer tail, but whether its function is unclear given the limited sequence similarity with CTR in yeast RTR1. | ||
| + | |||
| + | === Function === | ||
| + | Yeast RTR1 encodes the phosphatase that dephosphorylates serine-5 of CTD repeats of RNA pol II <cite>Mosley09 kim09</cite>. These findings were challenged by later studies <cite>xiang12</cite>, but more recent study supports its activity towards serine-5 <cite>hsu14</cite>. Moreover, it has been shown that Rtr1 dephosphorylates not only serine-5 but also the newly described anti-termination tyrosine 1 marker on CTD repeats <cite>hsu14</cite>. | ||
== Reference == | == Reference == | ||
| Line 10: | Line 16: | ||
#Kim09 pmid=19679665 | #Kim09 pmid=19679665 | ||
#xiang12 pmid=22781759 | #xiang12 pmid=22781759 | ||
| + | #hsu14 pmid=24951832 | ||
</biblio> | </biblio> | ||
Revision as of 16:56, 1 January 2015
Phosphatase Classification: Superfamily RTR1: Family RTR1
Evolution
RTR1 is found in most of eukaryotes. It is absent from Monosiga and sponge genome, though it is perhaps due to the quality of genome assembly. It is single copy in human, sea urchin, fruit fly, C elegans. However, two copies are found in yeast.
Domain
RTR1 has a conserved domain that carries out the phosphatase activity. Yeast RTR1 has a C-terminal region (CTR) that auto-inhibits the catalytic domain [1]. Human RTR1 encoded by gene RPAP2 has a longer tail, but whether its function is unclear given the limited sequence similarity with CTR in yeast RTR1.
Function
Yeast RTR1 encodes the phosphatase that dephosphorylates serine-5 of CTD repeats of RNA pol II [2, 3]. These findings were challenged by later studies [4], but more recent study supports its activity towards serine-5 [1]. Moreover, it has been shown that Rtr1 dephosphorylates not only serine-5 but also the newly described anti-termination tyrosine 1 marker on CTD repeats [1].
Reference
Error fetching PMID 19679665:
Error fetching PMID 22781759:
Error fetching PMID 24951832:
- Error fetching PMID 24951832:
- Error fetching PMID 19394294:
- Error fetching PMID 22781759:
- Error fetching PMID 19679665:
