Difference between revisions of "Phosphatase Fold HP"
From PhosphataseWiki
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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_PGM|Fold PGM]] | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_PGM|Fold PGM]] | ||
| − | PGM is short for Phosphoglycerate mutase. | + | PGM is short for Phosphoglycerate mutase. It can be classified as below <cite>jedrzejas00, rigden01</cite>: |
| − | * | + | |
| − | ** dependent on 23PGA as a cofactor (dPGM) | + | * Monophosphoglycerate mutase (mPGM) - catalyzes the interconversion of 3-phosphoglycerate (3PGA) and 2-phosphoglycerate (2PGA) |
| − | ** independent of 23PGA as a cofactor (iPGM) | + | ** dependent on 23PGA as a cofactor (dPGM) - found in animal, fungi, and bacteria |
| − | * | + | ** independent of 23PGA as a cofactor (iPGM) - found in plants, and bacteria |
| + | * Bisphosphoglycerate mutase (bPGM) - catalyzes primarily the interconversion of 1,3-phosphoglycerate (13PGA) and 23PGA | ||
| + | |||
| + | dPGM is also known as [[Phosphatase_Superfamily_HP|histidine phosphatase]]. | ||
| + | |||
| + | === References === | ||
| + | <biblio> | ||
| + | #jedrzejas00 pmid=10958932 | ||
| + | #rigden01 pmid=11514674 | ||
| + | </biblio> | ||
Revision as of 18:21, 1 January 2015
Phosphatase Classification: Fold PGM
PGM is short for Phosphoglycerate mutase. It can be classified as below [1, 2]:
- Monophosphoglycerate mutase (mPGM) - catalyzes the interconversion of 3-phosphoglycerate (3PGA) and 2-phosphoglycerate (2PGA)
- dependent on 23PGA as a cofactor (dPGM) - found in animal, fungi, and bacteria
- independent of 23PGA as a cofactor (iPGM) - found in plants, and bacteria
- Bisphosphoglycerate mutase (bPGM) - catalyzes primarily the interconversion of 1,3-phosphoglycerate (13PGA) and 23PGA
dPGM is also known as histidine phosphatase.
References
- Jedrzejas MJ. Structure, function, and evolution of phosphoglycerate mutases: comparison with fructose-2,6-bisphosphatase, acid phosphatase, and alkaline phosphatase. Prog Biophys Mol Biol. 2000;73(2-4):263-87. DOI:10.1016/s0079-6107(00)00007-9 |
- Rigden DJ, Bagyan I, Lamani E, Setlow P, and Jedrzejas MJ. A cofactor-dependent phosphoglycerate mutase homolog from Bacillus stearothermophilus is actually a broad specificity phosphatase. Protein Sci. 2001 Sep;10(9):1835-46. DOI:10.1110/ps.15701 |
