Difference between revisions of "Phosphatase Family RTR1"

Revision as of 22:10, 4 May 2014

Phosphatase Classification: Superfamily RTR1: Family RTR1

Rtr1 is a yeast gene that has been show to dephosphorylate Serine-5 of CTD repeats of RNA pol II [1, 2]. However, later research challenges these studies [3]. The human ortholog is RPAP2.

Reference

1. Mosley AL, Pattenden SG, Carey M, Venkatesh S, Gilmore JM, Florens L, Workman JL, and Washburn MP. Rtr1 is a CTD phosphatase that regulates RNA polymerase II during the transition from serine 5 to serine 2 phosphorylation. Mol Cell. 2009 Apr 24;34(2):168-78. DOI:10.1016/j.molcel.2009.02.025 | PubMed ID:19394294 | HubMed [Mosley09]
3. Xiang K, Manley JL, and Tong L. The yeast regulator of transcription protein Rtr1 lacks an active site and phosphatase activity. Nat Commun. 2012 Jul 10;3:946. DOI:10.1038/ncomms1947 | PubMed ID:22781759 | HubMed [xiang12]
4. Kim M, Suh H, Cho EJ, and Buratowski S. Phosphorylation of the yeast Rpb1 C-terminal domain at serines 2, 5, and 7. J Biol Chem. 2009 Sep 25;284(39):26421-6. DOI:10.1074/jbc.M109.028993 | PubMed ID:19679665 | HubMed [Kim09]