Difference between revisions of "Phosphatase Subfamily PPM1A"
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=== Evolution === | === Evolution === | ||
| − | The PPM1A subfamily is found | + | The PPM1A subfamily is found across [[Phosphatase_Glossary#holozoa|holozoan]]. |
PPM1N probably emerged in placentals and lost by independent evolutionary events in different lineages, as implied by [http://resdev.gene.com/gOrtholog/view/cluster/MC0033446/overview internal orthology database] and BLAST NR database. For BLAST, human PPM1N was defined as the hits that have a better (lower) E-values than human PPM1A and PPM1B. | PPM1N probably emerged in placentals and lost by independent evolutionary events in different lineages, as implied by [http://resdev.gene.com/gOrtholog/view/cluster/MC0033446/overview internal orthology database] and BLAST NR database. For BLAST, human PPM1N was defined as the hits that have a better (lower) E-values than human PPM1A and PPM1B. | ||
Revision as of 20:41, 3 June 2015
Phosphatase Classification: Fold PPM (PP2C): Superfamily PPM (PP2C): Family PPM (PP2C): Subfamily PPM1A
Evolution
The PPM1A subfamily is found across holozoan.
PPM1N probably emerged in placentals and lost by independent evolutionary events in different lineages, as implied by internal orthology database and BLAST NR database. For BLAST, human PPM1N was defined as the hits that have a better (lower) E-values than human PPM1A and PPM1B.
Functions
Human PPM1B
PPM1B is expressed in a broad types of tissues, most abundantly in skeletal muscle (see RNA-seq data from GTEx).
Human PPM1N
PPM1N's function is unknown. It is generally expressed at low level across tissues except spleen (see RNA-seq data from GTEx).
