Difference between revisions of "Phosphatase Subfamily TAB1"
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* TAK1 <cite>Shibuya96</cite> | * TAK1 <cite>Shibuya96</cite> | ||
* MEKK1 <cite>Charlaftis14</cite>. TAB1 is ubiquitinated by MEKK1 PHD domain. | * MEKK1 <cite>Charlaftis14</cite>. TAB1 is ubiquitinated by MEKK1 PHD domain. | ||
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| + | Human TAB1 is modified with N-acetylglucosamine (O-GlcNAc) on a single site, Ser-395. The modification is induced by IL-1 and osmotic stress, known inducers of the TAK1 signalling cascade. However, the serine at position 395 is only found in vertebrates. | ||
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=== References === | === References === | ||
<biblio> | <biblio> | ||
Revision as of 22:50, 8 June 2015
Phosphatase Classification: Fold PPM (PP2C): Superfamily PPM (PP2C): Family PPM (PP2C): Subfamily TAB1
Evolution
Domain
Function
Human TAB1 interacts with:
- TRAF6 []
- p38 [1, 2, 3]. TAB1 functions as a scaffold protein in the activation of p38 [3]
- TAK1 [4]
- MEKK1 [5]. TAB1 is ubiquitinated by MEKK1 PHD domain.
Human TAB1 is modified with N-acetylglucosamine (O-GlcNAc) on a single site, Ser-395. The modification is induced by IL-1 and osmotic stress, known inducers of the TAK1 signalling cascade. However, the serine at position 395 is only found in vertebrates.
References
- Ge B, Xiong X, Jing Q, Mosley JL, Filose A, Bian D, Huang S, and Han J. TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1. J Biol Chem. 2003 Jan 24;278(4):2286-93. DOI:10.1074/jbc.M210918200 |
- Lanna A, Henson SM, Escors D, and Akbar AN. The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells. Nat Immunol. 2014 Oct;15(10):965-72. DOI:10.1038/ni.2981 |
- Shibuya H, Yamaguchi K, Shirakabe K, Tonegawa A, Gotoh Y, Ueno N, Irie K, Nishida E, and Matsumoto K. TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. Science. 1996 May 24;272(5265):1179-82. DOI:10.1126/science.272.5265.1179 |
- Charlaftis N, Suddason T, Wu X, Anwar S, Karin M, and Gallagher E. The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. EMBO J. 2014 Nov 3;33(21):2581-96. DOI:10.15252/embj.201488351 |
- Zhu Y, Regunath K, Jacq X, and Prives C. Cisplatin causes cell death via TAB1 regulation of p53/MDM2/MDMX circuitry. Genes Dev. 2013 Aug 15;27(16):1739-51. DOI:10.1101/gad.212258.112 |
