Difference between revisions of "HMM PD00127"
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Revision as of 17:13, 9 September 2015
Description
The HMM extends Pfam profile Pur_ac_phosph_N, which cannot detect the domain in some phosphatases, such as C. elegans ACP5 (Phosphatase_Sequence_CeleP014_AA).
How the HMM is built
We searched the Pfam domains of C. elegans ACP5 (Phosphatase_Sequence_CeleP014_AA) and human ACP5 via Pfam server. Based upon the position of Metallophos domain and the length of the linking region between Metallophos and Pur_ac_phosph_N domain, we guessed the region of 1-100 of C. elegans ACP5 (Phosphatase_Sequence_CeleP014_AA) may contain the Pur_ac_phosph_N domain.
We then PSI-BLASTed the region against NR database via NCBI BLAST server.
