Difference between revisions of "Phosphatase Subfamily TIMM50"
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Revision as of 17:27, 2 October 2015
Phosphatase Classification: FCP: TIMM50
TIMM50 (or TIM50) is named after translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) [1] [2]. It is a subunit of the TIM23 complex that links protein translocation across the outer and inner mitochondrial membranes. It lacks the DxDx[T|V] motif at catalytic site.
Evolution
TIMM50 is conserved from yeast to human.
Domain Structure
Catalytic activity
TIMM50 has been show to possess a phosphatase activity toward both phospho-serine/threonine and phospho-tyrosine in vitro assay [3].
Related Kinases
1) Raf. High throughput yeast two-hybrid assay show Raf kinase can interact with TIMM50, as well as FCP1. The paper also guessed Raf is the substrate of TIMM50 [4], but actually TIMM50 lacks the catalytic motif. (Note: Raf also interacts with FCP1 in the paper).
Curation notes
References
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Error fetching PMID 16763150:
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- Error fetching PMID 16763150:
- Error fetching PMID 12620389:
Links
Human TIMM50 from NCBI Gene
