Difference between revisions of "Phosphatase Superfamily RTR1"
| Line 5: | Line 5: | ||
=== Evolution === | === Evolution === | ||
| − | RTR1 is found in most | + | RTR1 is found in most eukaryotes. It is absent from the sponge genome, though it is perhaps due to the quality of genome assembly. It is single copy in human, sea urchin, fruit fly, ''C elegans''. However, two copies are found in yeast (RTR1, RTR2). |
| − | === Domain === | + | === Domain Structure=== |
| − | RTR1 has a conserved | + | RTR1 has a conserved phosphatase domain with a unique mechanism of action <cite>Irani</cite>. Yeast RTR1 has a C-terminal region (CTR) that auto-inhibits the catalytic domain <cite>hsu14</cite>. The human homolog, RPAP2, has a longer tail with limited sequence similarity to CTR, and is known to bind RNA pol II subunit Rpb6 and to be involved in pre-mRNA 3'-end formation <cite>Wani</cite>. |
=== Function === | === Function === | ||
| − | Yeast RTR1 | + | Yeast RTR1 dephosphorylates serine-5 of CTD repeats of RNA pol II <cite>Mosley09 kim09</cite>. These findings were challenged by later studies <cite>xiang12</cite>, but more recent study supports its activity towards serine-5 <cite>hsu14</cite> and also the anti-termination tyrosine-1 on CTD repeats <cite>hsu14</cite>. |
=== References === | === References === | ||
<biblio> | <biblio> | ||
#Mosley09 pmid=19394294 | #Mosley09 pmid=19394294 | ||
| + | #Wani pmid= 25639305 | ||
| + | #Irani pmid=26933063 | ||
#Kim09 pmid=19679665 | #Kim09 pmid=19679665 | ||
#xiang12 pmid=22781759 | #xiang12 pmid=22781759 | ||
#hsu14 pmid=24951832 | #hsu14 pmid=24951832 | ||
</biblio> | </biblio> | ||
Revision as of 20:58, 17 October 2016
Phosphatase Classification: Fold RTR1: Superfamily RTR1
RTR1 is a phosphatase conserved in eukaryotes that regulates the phosphorylation states of C-terminal domain (CTD) of RNA polymerase II.
Evolution
RTR1 is found in most eukaryotes. It is absent from the sponge genome, though it is perhaps due to the quality of genome assembly. It is single copy in human, sea urchin, fruit fly, C elegans. However, two copies are found in yeast (RTR1, RTR2).
Domain Structure
RTR1 has a conserved phosphatase domain with a unique mechanism of action [1]. Yeast RTR1 has a C-terminal region (CTR) that auto-inhibits the catalytic domain [2]. The human homolog, RPAP2, has a longer tail with limited sequence similarity to CTR, and is known to bind RNA pol II subunit Rpb6 and to be involved in pre-mRNA 3'-end formation [3].
Function
Yeast RTR1 dephosphorylates serine-5 of CTD repeats of RNA pol II [4, 5]. These findings were challenged by later studies [6], but more recent study supports its activity towards serine-5 [2] and also the anti-termination tyrosine-1 on CTD repeats [2].
References
Error fetching PMID 26933063:
Error fetching PMID 19679665:
Error fetching PMID 22781759:
Error fetching PMID 24951832:
- Error fetching PMID 26933063:
- Error fetching PMID 24951832:
- pmid= 25639305
- Error fetching PMID 19394294:
- Error fetching PMID 22781759:
- Error fetching PMID 19679665:
