Difference between revisions of "Phosphatase Subfamily PRL"

Revision as of 01:21, 28 December 2014

Phosphatase Classification: Superfamily CC1: Family DSP and PTEN: Subfamily PRL

PRL is short for Phosphatases of Regenerating Liver. There are three PRLs in human, PRL1, PRL2, PRL3, all of which have been identified as key contributors to metastasis in several human cancers [1, 2]. PRL subfamily is present in animals, amoeba, and many basal eukaryotes, but is absent from fungi and plants (unpublish data from gOrtholog). The molecular mechanisms of PRL phosphatases is reviewed at here [3] in 2012, but it may play other roles as more works are going-on (e.g. [1]).

Reference

1. Hardy S, Uetani N, Wong N, Kostantin E, Labbé DP, Bégin LR, Mes-Masson A, Miranda-Saavedra D, and Tremblay ML. The protein tyrosine phosphatase PRL-2 interacts with the magnesium transporter CNNM3 to promote oncogenesis. Oncogene. 2015 Feb 19;34(8):986-95. DOI:10.1038/onc.2014.33 | PubMed ID:24632616 | HubMed [tremblay14]
2. Stephens BJ, Han H, Gokhale V, and Von Hoff DD. PRL phosphatases as potential molecular targets in cancer. Mol Cancer Ther. 2005 Nov;4(11):1653-61. DOI:10.1158/1535-7163.MCT-05-0248 | PubMed ID:16275986 | HubMed [Von-Hoff06]
3. Rios P, Li X, and Köhn M. Molecular mechanisms of the PRL phosphatases. FEBS J. 2013 Jan;280(2):505-24. DOI:10.1111/j.1742-4658.2012.08565.x | PubMed ID:22413991 | HubMed [kohn12]