Difference between revisions of "Phosphatase Subfamily PTPRC"
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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPRC|Subfamily PTPRC]] | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPRC|Subfamily PTPRC]] | ||
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| − | + | PTPRC (CD45) is a vertebrate-specific receptor PTP involved in immune signaling. | |
| − | PTPRC (CD45) is a vertebrate-specific receptor PTP involved in immune signaling | + | |
===Evolution=== | ===Evolution=== | ||
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===Functions=== | ===Functions=== | ||
| − | CD45 modulates immune function. It is selectively expressed on lymphocytes and dephosphorylates and activates the src family tyrosine kinases lck, fyn and lyn in B and T cells. | + | CD45 modulates immune function. It is selectively expressed on lymphocytes and dephosphorylates and activates the [http://kinase.com/wiki/index.php/Kinase_Family_Src src family] tyrosine kinases lck, fyn and lyn in B and T cells. |
===References=== | ===References=== | ||
<biblio> | <biblio> | ||
</biblio> | </biblio> | ||
Revision as of 03:24, 28 December 2014
Phosphatase Classification: Superfamily CC1: Family PTP: Subfamily PTPRC
PTPRC (CD45) is a vertebrate-specific receptor PTP involved in immune signaling.
Evolution
PTPRC is found as a single-copy gene in all vertebrates, including the lamprey, but not in any invertebrate.
Domain Structure
PTPRC has twin intracellular PTP phosphatase domains, and extracellular FN3 domains, plus a CD45-specific and a PTP-N-terminal domain found specifically in PTPRC, as annotated by InterPro. CD45 is extensively alternatively spliced.
Functions
CD45 modulates immune function. It is selectively expressed on lymphocytes and dephosphorylates and activates the src family tyrosine kinases lck, fyn and lyn in B and T cells.
