Phosphatase Subfamily PPM1A

Phosphatase Classification: Fold PPM (PP2C): Superfamily PPM (PP2C): Family PPM (PP2C): Subfamily PPM1A

Evolution

The PPM1A subfamily is found across holozoan.

PPM1N probably emerged in placentals and lost by independent evolutionary events in different lineages, as implied by internal orthology database and BLAST NR database. For BLAST, human PPM1N was defined as the hits that have a better (lower) E-values than human PPM1A and PPM1B.

Functions

Human PPM1B

PPM1B is expressed in a broad types of tissues, most abundantly in skeletal muscle (see RNA-seq data from GTEx).

Human PPM1N

PPM1N's function is unknown. It is generally expressed at low level across tissues except spleen (see RNA-seq data from GTEx).

Fruit fly alph (alphabet)

Alphabet, the PPM1A in fruit fly, negatively regulates RAS/MAPK signaling in Drosophila [1].

References

1. Baril C and Therrien M. Alphabet, a Ser/Thr phosphatase of the protein phosphatase 2C family, negatively regulates RAS/MAPK signaling in Drosophila. Dev Biol. 2006 Jun 1;294(1):232-45. DOI:10.1016/j.ydbio.2006.02.046 |