Phosphatase Subfamily PPM1A
Phosphatase Classification: Fold PPM (PP2C): Superfamily PPM (PP2C): Family PPM (PP2C): Subfamily PPM1A
Contents
Evolution
The PPM1A subfamily is found across holozoan.
PPM1N probably emerged in placentals and lost by independent evolutionary events in different lineages, as implied by internal orthology database and BLAST NR database. For BLAST, human PPM1N was defined as the hits that have a better (lower) E-values than human PPM1A and PPM1B.
Functions
Human PPM1A
Human PPM1B
PPM1B is expressed in a broad types of tissues, most abundantly in skeletal muscle (see RNA-seq data from GTEx). It dephosphorylates serine-172 of kinase TBK1 and negatively regulates antiviral response [1].
Human PPM1N
PPM1N's function is unknown. It is generally expressed at low level across tissues except spleen (see RNA-seq data from GTEx).
Fruit fly alph (alphabet): negatively regulates RAS/MAPK and SAPK
Alphabet, the PPM1A in fruit fly, negatively regulates RAS/MAPK signaling in Drosophila [2] and stress-activated protein kinase (SAPK) [3]. However, its substrates in these signaling pathways are unclear.
References
- Zhao Y, Liang L, Fan Y, Sun S, An L, Shi Z, Cheng J, Jia W, Sun W, Mori-Akiyama Y, Zhang H, Fu S, and Yang J. PPM1B negatively regulates antiviral response via dephosphorylating TBK1. Cell Signal. 2012 Nov;24(11):2197-204. DOI:10.1016/j.cellsig.2012.06.017 |
- Baril C and Therrien M. Alphabet, a Ser/Thr phosphatase of the protein phosphatase 2C family, negatively regulates RAS/MAPK signaling in Drosophila. Dev Biol. 2006 Jun 1;294(1):232-45. DOI:10.1016/j.ydbio.2006.02.046 |
- Baril C, Sahmi M, Ashton-Beaucage D, Stronach B, and Therrien M. The PP2C Alphabet is a negative regulator of stress-activated protein kinase signaling in Drosophila. Genetics. 2009 Feb;181(2):567-79. DOI:10.1534/genetics.108.096461 |
