Phosphatase Subfamily PPM1K

Phosphatase Classification: Fold PPM (PP2C): Superfamily PPM (PP2C): Family PPM (PP2C): Subfamily PPM1K (PP2Cκ, PP2Cm, BDP)

Evolution

The PPM1K subfamily probably emerged in holozoa. It was lost in ecdysozoa and sponge. Monosiga brevicollis PPM1K has accessory EF-hand domains at C-terminal.

Domain

The PPM1K subfamily has an N-terminal mitochondria target signal (MTS) and phosphatase domain [1, 2]. The MTS (predicted by MitoProt) and phosphatase domain are conserved throughout the PPM1K subfamily.

Functions

Human PPM1K is widely expressed in different tissues, most abundant in heart as shown in [1, 2] and GTEx database. Human PPM1K is localized to mitochondrial matrix [2]. It regulates mitochondrial membrane permeability transition pore (MPTP) opening, but the underlying molecular mechanism(s) is unclear [2]. It also functions as pSer phosphatase of the branched-chain a-keto acid dehydrogenase complex [1].

References

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