Pseudophosphatases

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List of pseudophosphatases

HP fold

HP1 family

PFKFB subfamily

PFKFB has two enzymatic domains: 6-phosphofructo-2-kinase domain and fructose-2,6-bisphosphatase domain.

• Human PFKFB3 has low bisphosphatase activity, which is probably due to the R to S substitution at R motif [1, 2].
• Yeast PFK26 is inactive as indicated by the fructose-2,6-bisphosphatase moiety [3], which probably due to H to S substitution at RH motif.
• Yeast YLR345W is predicted to be inactive, since the substitution of H by C at RH motif is observed.

STS subfamily

C. elegans has an expansion in STS subfamily. It has five members, however, none of them has SH3 or UBA domain that are common among STSs. We observed substitutions in three STSs from RH..R..Hx to RC..A..Ds, --..K..Dn, RS..R..Ha, respectively.

Note: old version Pseudophosphatases (obsolete)

References

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