Phosphatase Subfamily UBLCP1
From PhosphataseWiki
Contents
Phosphatase Classification: FCP:UBLCP1
Introduction
UBLCP1 is named after Ubiquitin-like domain containing CTD phosphatase 1. It has an accessary N-terminal domain, similar to ubiquitin. Its function is not well characterized, though in vitro assay showed its phosphatase activity toward RNA polymerase II C-terminal domain [1].
Related Kinases
See Phosphorylation of RNA polymerase II C-terminal domain.
Evolutionary History
It is conserved from Nematostella to human but lost in nematode. However, UBLCP1-like proteins can be found in plant.
Domain Combination
Catalytic activity
It has a different catalytic motif from other subfamilies of FCP.
Curation notes
References
- Zheng H, Ji C, Gu S, Shi B, Wang J, Xie Y, and Mao Y. Cloning and characterization of a novel RNA polymerase II C-terminal domain phosphatase. Biochem Biophys Res Commun. 2005 Jun 17;331(4):1401-7. DOI:10.1016/j.bbrc.2005.04.065 |
Links
Human UBLCP1 from NCBI Gene
