Phosphtase Subfamily CDC25

Phosphatase Classification: Superfamily Cys-based II (Rhondanese): Family CDC25: Subamily CDC25

CDC25 composes of a catalytic domain on the C-terminus [1, 2], and a less-conserved N-terminal regulatory region [3], which can be phosphorylated and ubiquitinated. CDC25 activates cyclin-dependent kinases (CDKs) by dephosphorylating two sites within their ATP binding loop. CDKs regulate key transitions between cell cycle phases, and are key components of the checkpoint pathways involved in DNA damage. Thus, it is not suppressing to find it overexpressed in many human cancers [4].

CDC25s can be found through the unikonts (fungi, animal, amoebazoans), and in a few other eukaryotes. Within plants, they are only found in the alga Ostreococcus, but not Chalmydomonas, and are absent from land plants. In excavates, they are found in Trichomonas, but not Giardia, Leishmania, or Trypanosomes.

References

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