Phosphatase Superfamily CC1

Phosphatase classification: Superfamily CC1

CC1 (or Cysteine-based, group 1) is the largest phosphatase superfamily. It consists of three families in human: Classic PTP (Protein Tyrosine Phosphatase; generally tyrosine specific), DSP and PTEN (Dual Specificity Phosphatases; tyr/ser/thr specific) and Myotubularin (lipid specific). Fungi, plants and many protists also have the OCA family.

It shares a Cys-based catalytic motif, CX5R with another two superfamilies Cys-based I and Cys-based III, but it has distinct structure from them.