Phosphatase Family OCA

Phosphatase Classification: Superfamily CC1: OCA

OCA family is named after the five member genes in yeast. OCA stands for Oxidant-induced Cell-cycle Arrest. The physiological substrates of OCAs are still unclear. But, OCA3 has been shown to control intracellular localization of Gln3 (a phosphorylated transcriptional activator), in cooperation with Npr1 kinase [1]. OCAs also have been shown to be involved in telomere capping and uncapping [2].

It is found in most if not all of eukaryotes except eumetazoan (i.e. fungi, plants, protists, monosiga, and sponge).

The family is also called as plant and fungi atypical (PFA)-DSPs [3, 4].

Reference

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