Phosphatase Subfamily PTPRG

Phosphatase Classification: Superfamily CC1: Family PTP: Subfamily PTPRG

(Summary)

Evolution

PTPRG is found in eumetazoans, typically single-copy, but expanded to two genes, PTPRG and PTPRZ in human and other vertebrates.

Domain Structure

These are receptor PTPs with dual intracellular catalytic domains. The extracellular domain contains at least one FN3 domain. Vertebrate members have a catalytically inactive carbonic anhydrase (CA) domain, while most invertebrates, including one invertebrate chordate, have additional Ig and FN3 repeats instead. The CA domain acts as a receptor for members of the contactin family of neural cell adhesion molecules [1].

References

1. Bouyain S and Watkins DJ. The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules. Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2443-8. DOI:10.1073/pnas.0911235107 |