Phosphatase Subfamily CDC25

Phosphatase Classification: Fold CC3 (Rhondanese): Superfamily CC3 (Rhondanese): Family CDC25: Subfamily CDC25

Evolution

CDC25 subfamily is found in a broad of eukaryotes, but absent from most if not all of plants. It has multiple copies in some if not many genomes. For example, human, fruit fly and C elegans have 3, 2, 4, respectively, and they do not fall into 1:1 orthologous relationship.

Domain

Human CDC25s have N-terminal regulatory domain and phosphatase domain. Due to alternative splicing, the isoforms of human CDC25s have different sequences at regulatory domain region.