Phosphatase Subfamily CDC25

Phosphatase Classification: Fold CC3 (Rhondanese): Superfamily CC3 (Rhondanese): Family CDC25: Subfamily CDC25

Evolution

CDC25 subfamily is found in a broad of eukaryotes, but absent from most if not all of plants. It has multiple copies in some if not many genomes. For example, human, fruit fly and C elegans have 3, 2, 4, respectively, and they do not fall into 1:1 orthologous relationship.

Domain

Human CDC25s have N-terminal regulatory domain and phosphatase domain. Due to alternative splicing, the isoforms of human CDC25s have different sequences at regulatory domain region.

Catalytic activity and functions

Cdc25 phosphatases, as activators of the Cdk/cyclins, play critical roles in the regulation of the eukaryotic cell cycle. Their structures and functions have been reviewed in details [1, 2, 3].