Phosphatase Subfamily STYX

is a pseudophosphatase subfamily with a single human member. STYX localizes to the nucleus, competes with DUSP4 for binding to ERK, and acts as a nuclear anchor that regulates ERK nuclear export [1]. The subfamily is found in most opisthokonts but lost in nematodes. Although It is not found in Drosophila and budding yeast, it is found in other arthropoda and fungi (unpublished data from gOrtholog).