Phosphatase Subfamily PPM1Z
Phosphatase Classification: Fold PPM (PP2C): Superfamily PPM (PP2C): Family PPM (PP2C): Subfamily PTC2
Evolution
The PTC2 subfamily is conserved in opisthokont but lost in human, sponge and monosiga. Its sequence is most similar to PPM1G, but it lacks , and 2) it also has a N-terminal myristoylation site. It Notice: Monosiga has a unclassified phosphatase that has a N-terminal myristoylation site but the overall sequence similarity does not well support it is PPM1G2.
Domain
The PPM1G2 subfamily has a N-terminal myristoylation site and a phosphatase domain. The phosphatase domain is closer to PPM1G than other PPMs in sequence, but it does not have the acidic domain inserted in catalytic domain which is common in PPM1G subfamily.
Functions
The most studied members of PPM1G2 subfamily are yeast PTC2, PTC3 and PTC4, whose functions were summarized in Table 1 of [1].
