Phosphatase Subfamily PPP5C

Phosphatase Classification: Fold MTDP: Superfamily MTDP: Family PPP: Subfamily PPP5C

Evolution

The PPP5C subfamily is found throughout eukaryotes, including opisthokonta, amoebazoa, plants and etc. PPP5Cs have tandem tetratricopeptide repeat (TPR) structural motifs at N-terminal, which distinguish them from other PPP subfamilies, and were used to find and classify PPP5C in yeast and dicty in phosphatome.net database.

Domain

PPP5Cs typically have tandem tetratricopeptide repeats (TPRs) at N-terminal and phosphatase domain at C-terminal. Dictystelium has an additional but partial TPR of ~30 aa residues.

Functions

PPP5C is the catalytic subunit of holoenzyme PP5, the function of which is reviewed at [1].

References

1. Zhong J, Liao J, Liu X, Wang P, Liu J, Hou W, Zhu B, Yao L, Wang J, Li J, Stark JM, Xie Y, and Xu X. Protein phosphatase PP6 is required for homology-directed repair of DNA double-strand breaks. Cell Cycle. 2011 May 1;10(9):1411-9. DOI:10.4161/cc.10.9.15479 |