Phosphatase Family LMWPTP

Function

In eukaryotes, LMWPTP dephosphorylate many receptor tyrosine kianses, such as platelet-derived growth factor receptor (PDGFR), insulin receptor (InsR), or ephrin receptor (Eph) [1].

In prokaryotes, the molecular function is not fully understood. It is involved in the syntheisis and translocation of exopolysaccharides (EPS) and capsular polysaccharides (CPS) in E. coli.

Evolution

The LMWPTP is present not only in eukaryotes but also prokaryotes. In eukaryotes, it is generally absent from alveolates, trypanosoma, leishmania.

Comparison of the catalytic site with LMW-PTP

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LMW-PTP

Ssu72

Sequence logo of catalytic site of Ssu72 and LMW-PTP. The logo of Ssu72 was built from 33 sequences, and that of LMW-PTP from 42 sequences including five known prokaryotic LMW-PTPs.

Reference

1. Kikawa KD, Vidale DR, Van Etten RL, and Kinch MS. Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation. J Biol Chem. 2002 Oct 18;277(42):39274-9. DOI:10.1074/jbc.M207127200 |