Phosphatase Family Myotubularin
Phosphatase Classification: Superfamily CC1: Myotubularin
Myotubularins are 3-phosphatases specific for PtdIns3P and PtdIns(3,5)P2, two PIs that function within the endosomal-lysomal pathway . In yeast, there is a single myotubularin Ymr1p, and its functions appear to be redundant with those of other 3-phosphatases. However, in C. elegans, which has six myotubularins, several of the myotublarins have non-redundant roles in regulating PtdIns3P during endocytosis. In human, there are 14 myotublarins, and mutations in several of them lead to myotubular myopathy and Charcot-Marie-Tooth peripheral neuropathy. Interestingly, around half of myotubularins are catalytically inactive. One of their possible function is regulating active myotubularins by protein interaction. For details, see the review [1].
Contents
[hide]Subfamilies
MTMR1 subfamily
MTMR3 subfamily
MTMR5 subfamily
Inactive myotubularin subfamily.
MTMR1 subfamily
MTMR9 subfamily
MTMR10 subfamily
MTMR14 subfamily
C2-MTMR1 subfamily
The feature of this subfamily is a C2 domain attached to the R1-like sequence.