Phosphatase Subfamily PPP1C
From PhosphataseWiki
Phosphatase Classification: Fold MTDP: Superfamily MTDP: Family PPP: Subfamily PPP1C
Evolution
The PPP1Cs have many lineage-specific gene duplications. In particular, 10 PPP1Cs are found in fruit fly, while 3 in human, 3 in C. elegans, and 4 in yeast.
Functions
PPP1C also called PP1 is the catalytic subunit binding to regulatory subunits to achieve diverse functions [1]. Over 50 different regulatory subunits are known in human and at least 20 in yeast. These different complexes play key roles in various cellular processes from cell cycle progression [2] to glycogen metabolism.
References
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