Phosphatase Subfamily PAPL

Phosphatase Classification: Fold MTDP:Superfamily MTDP: Family PAP: PAPL

Evolution

PAPL subfamily is found in holozoa but lost from most arthropods. Humans have a single member, PAPL, but many invertebrates have multiple members

Domain Structure

PAPL has a phosphatase domain and a signal peptide cleavage site on N-terminus. Though predicted to be secreted, human PAPL is found mostly in the cytoplasm (http://www.proteinatlas.org/ENSG00000183760-PAPL/tissue).

Function

Unclear.