Phosphatase Family PAP

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Phosphatase Classification: Fold PPPL: Superfamily PPPL: Family PAP (purple acid phosphatase)

PAP (Purple Acid Phosphatase is found in most eukaryotes, even in some prokaryotes. It has three eukaryotic subfamilies, the first two present in human:

  • ACP5 is found in most eukaryotes. Human ACP5 hydrolyzes a variety of phosphomonoesters at acidic pH in vitro. It also shows phosphatase activity towards the protein osteopontin, and the mannose 6-phosphate modification on lysosomal proteins.
  • PAPL is found in holozoa, but is lost in most arthropods. Its function is unclear.
  • DCR2 is present in most fungi, most plants and some chromalveolates.