Phosphatase Family PAP
PAP (Purple Acid Phosphatase is found in most eukaryotes, even in some prokaryotes. It has three eukaryotic subfamilies, the first two present in human:
- ACP5 is found in most eukaryotes. Human ACP5 hydrolyzes a variety of phosphomonoesters at acidic pH in vitro. It also shows phosphatase activity towards the protein osteopontin, and the mannose 6-phosphate modification on lysosomal proteins.
- PAPL is found in holozoa, but is lost in most arthropods. Its function is unclear.
- DCR2 is present in most fungi, most plants and some chromalveolates.