Phosphatase Subfamily DCR2

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Phosphatase Classification: Fold PPPL: Superfamily PPPL: Family PAP: DCR2


The DCR2 subfamily is found in most fungi, most plants and a few chromalveolates.

Domain Structure

DCR2 has a single phosphatase domain.


DCR2 dephosphorylates Ire1, a conserved endoplasmic reticulum transmembrane UPR sensor in Saccharomyces cerevisiae [1].


  1. Guo J and Polymenis M. Dcr2 targets Ire1 and downregulates the unfolded protein response in Saccharomyces cerevisiae. EMBO Rep. 2006 Nov;7(11):1124-7. DOI:10.1038/sj.embor.7400813 | PubMed ID:16990850 | HubMed [Guo06]