Phosphatase Subfamily PPM1Z

Phosphatase Classification: Fold PPM (PP2C): Superfamily PPM (PP2C): Family PPM (PP2C): Subfamily PPM1G2

Evolution

The PPM1G2 subfamily is conserved in opisthokont but lost in human, sponge and monosiga. It is named as PPM1G2, because 1) its sequence is more similar to PPM1G than other PPMs, and 2) it also has a N-terminal myristoylation site.

Domain

The PPM1G2 subfamily has a N-terminal myristoylation site and a phosphatase domain. The phosphatase domain is closer to PPM1G than other PPMs in sequence, but it does not have the acidic domain inserted in catalytic domain which is common in PPM1G subfamily.