Phosphatase Subfamily FCP1

Introduction

F-cell production 1 (FCP1) also called TFIIF-stimulated CTD phosphatase 1, prefers to dephosphorylate pSer2 of heptapeptide repeats at CTD of RNA polymerase II. The molecular function is mainly studied in yeast [1].

Substrates and Related Kinases

See Phosphorylation of RNA polymerase II C-terminal domain.

Evolutionary History

FCP1 is conserved from yeast to human, usually one copy per genome.

Domain Combination

In additional to the catalytic domain, it has a breast cancer protein-related carboxy-terminal (BRCT) domain and a C-terminal region that binds regulatory TFIIF.

References

1. Kamenski T, Heilmeier S, Meinhart A, and Cramer P. Structure and mechanism of RNA polymerase II CTD phosphatases. Mol Cell. 2004 Aug 13;15(3):399-407. DOI:10.1016/j.molcel.2004.06.035 |

Links

Human FCP1 from NCBI Gene