Phosphatase Subfamily TAB1

Phosphatase Classification: Fold PPM (PP2C): Superfamily PPM (PP2C): Family PPM (PP2C): Subfamily TAB1

Function

Human TAB1 interacts with:

• TRAF6 []
• p38 [1, 2, 3]. TAB1 functions as a scaffold protein in the activation of p38 [3]
• TAK1 [4]
• MEKK1 [5]. TAB1 is ubiquitinated by MEKK1 PHD domain.

Human TAB1 is modified with N-acetylglucosamine (O-GlcNAc) on a single site, Ser-395. The modification is induced by IL-1 and osmotic stress, known inducers of the TAK1 signalling cascade. However, the serine at position 395 is only found in vertebrates.

References

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