HMM PD0006

The PTP domain has been described to consist of ~􏰔280 amino acids [1]. However, the region of the first two helices at the N terminus are not as conserved as other regions and the C-terminus in invertebrates. We use vertebrate PTP phosphatase domain profile to define the boundaries. However, it is not a perfect HMM profile to define the N-terminal boundary.

References

1. Andersen JN, Mortensen OH, Peters GH, Drake PG, Iversen LF, Olsen OH, Jansen PG, Andersen HS, Tonks NK, and Møller NP. Structural and evolutionary relationships among protein tyrosine phosphatase domains. Mol Cell Biol. 2001 Nov;21(21):7117-36. DOI:10.1128/MCB.21.21.7117-7136.2001 |