Phosphatase Subfamily TIMM50

Introduction

TIMM50 (or TIM50) is named after translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) [1] [2]. It is a subunit of the TIM23 complex that links protein translocation across the outer and inner mitochondrial membranes. It lacks the DxDx[T|V] motif at catalytic site.

Related Kinases

1) Raf. High throughput yeast two-hybrid assay show Raf kinase can interact with TIMM50, as well as FCP1. The paper also guessed Raf is the substrate of TIMM50 [3], but actually TIMM50 lacks the catalytic motif. (Note: Raf also interacts with FCP1 in the paper).

Evolutionary History

TIMM50 is conserved from yeast to human, while Raf is conserved from sponge to human.

Catalytic activity

No.

References

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Links

Human TIMM50 from NCBI Gene