Phosphatase Subfamily LPPR

The subfamily LPPR has five genes in human, LPPR1-5. LPPR3 (PRG-1) has been reported to be a phospholipid phosphatase [1]. However, it is controversial [2].

1. Bräuer AU, Savaskan NE, Kühn H, Prehn S, Ninnemann O, and Nitsch R. A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting. Nat Neurosci. 2003 Jun;6(6):572-8. DOI:10.1038/nn1052 |
2. McDermott MI, Sigal YJ, Sciorra VA, and Morris AJ. Is PRG-1 a new lipid phosphatase?. Nat Neurosci. 2004 Aug;7(8):789; author reply 789-90. DOI:10.1038/nn0804-789a |