Phosphatase Subfamily PPP1C
From PhosphataseWiki
Phosphatase Classification: Fold MTDP: Superfamily PPP: Family PPP: Subfamily PPP1C
Evolution
The PPP1Cs have many lineage-specific gene duplications. In particular, 10 PPP1Cs are found in fruit fly, while 3 in human, 3 in C. elegans, and 4 in yeast.
Functions
PPP1C also called PP1 is the catalytic subunit binding to regulatory subunits to achieve diverse functions [1]. Over 50 different regulatory subunits are known in human and at least 20 in yeast. These different complexes play key roles in various cellular processes from cell cycle progression [2] to glycogen metabolism.
References
- Heroes E, Lesage B, Görnemann J, Beullens M, Van Meervelt L, and Bollen M. The PP1 binding code: a molecular-lego strategy that governs specificity. FEBS J. 2013 Jan;280(2):584-95. DOI:10.1111/j.1742-4658.2012.08547.x |
- Grallert A, Boke E, Hagting A, Hodgson B, Connolly Y, Griffiths JR, Smith DL, Pines J, and Hagan IM. A PP1-PP2A phosphatase relay controls mitotic progression. Nature. 2015 Jan 1;517(7532):94-98. DOI:10.1038/nature14019 |
