Phosphatase Subfamily PTPRC

Phosphatase Classification: Superfamily CC1: Family PTP: Subfamily PTPRC

PTPRC (CD45) is a vertebrate-specific receptor PTP involved in immune signaling.

Evolution

PTPRC is found as a single-copy gene in all vertebrates, including the lamprey, but not in any invertebrate.

Domain Structure

PTPRC has twin intracellular PTP phosphatase domains, and extracellular FN3 domains, plus a CD45-specific and a PTP-N-terminal domain found specifically in PTPRC, as annotated by InterPro. CD45 is extensively alternatively spliced.

Functions

CD45 modulates immune function. It is selectively expressed on lymphocytes and dephosphorylates and activates the src family tyrosine kinases lck, fyn and lyn in B and T cells.