Phosphatase Subfamily VSP

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Phosphatase Classification: Superfamily CC1: Family PTEN: Subfamily VSP

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The Voltage Sensitive Phosphatase (VSP) members consist of a voltage sensor consisting of four transmembrane segments, in addition to phosphatase domain and C2 domain. It has two members in human, TPTE and TPTE2 (TPIP), but TPTE is a pseudophosphatase. The subfamily is conserved in holozoa but absent from nematodes and most arthropods. It usually has a single copy in each species, and the two human copies appear to be a primate duplication.

Evolution

VSPs are holozoan-specific and lost in both nematodes and insects. There are two human genes, TPTE (PTEN2) and TPTE2 (TPIP).

Domain Structure

VSPs consist of an N-terminal voltage sensor with four transmembrane regions, followed by a phosphatase domain and a PTEN_C2 domain

Functions

Both human genes are testis specific (GTEx: TPTE, TPTE2) and are localized to the Golgi apparatus [1]

References

  1. []
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