Phosphatase Subfamily SCP

Introduction

SCP is named after Small CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase. This subfamily has three members in human, SCP1 (or CTDSP1), SCP2 (or CTDSP2), and SCP3 (or CTDSPL). They are present in neuronal progenitor cells and nonneuronal cells and targets neuronal genes by interacting with the REST/NRSF complext. The SCP1 is a transcriptional corepressor for inhibiting neuronal gene transcription in non-neuronal cells. For its molecular function, the SCP1 prefers to dephosphorylate pSer5 at CTD [1].

Substrates and Related Kinases

See Phosphorylation of RNA polymerase II C-terminal domain.

Evolutionary History

SCP is conserved from yeast to human.

References

1. Zhang Y, Kim Y, Genoud N, Gao J, Kelly JW, Pfaff SL, Gill GN, Dixon JE, and Noel JP. Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1. Mol Cell. 2006 Dec 8;24(5):759-770. DOI:10.1016/j.molcel.2006.10.027 |

Links

Human CTDSP1, CTDSP2, and CTDSPL from NCBI Gene