Phosphatase Subfamily SCP

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Phosphatase Classification: Fold HAD: Superfamily HAD: Family FCP: Subfamily SCP (Small CTD Phosphatase)

SCP is named after Small CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase.


SCP is conserved from yeast to human. The SCP subfamily has three members in human, SCP1 (or CTDSP1), SCP2 (or CTDSP2), and SCP3 (or CTDSPL). CTDSPL2 is a member of a different subfamily.

Domain Combination

SCP has a single phosphatase domain of HAD fold.


Human SCPs are present in neuronal progenitor cells and nonneuronal cells and targets neuronal genes by interacting with the REST/NRSF complex.


Human SCP1 prefers to dephosphorylate pSer5 at CTD [1]. See Phosphorylation of RNA polymerase II C-terminal domain for other CTD phosphatases.

SCP1 also dephosphorylates c-Myc at Serine-62 which affects its stability in cancer cells [2].

The SCP1 is a transcriptional corepressor for inhibiting neuronal gene transcription in non-neuronal cells.


SCP3 dephosphorylates the linker sites of R-Smads to ensure TGFβ-mediated germ layer induction in Xenopus embryos [3].


  1. Zhang Y, Kim Y, Genoud N, Gao J, Kelly JW, Pfaff SL, Gill GN, Dixon JE, and Noel JP. Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1. Mol Cell. 2006 Dec 8;24(5):759-770. DOI:10.1016/j.molcel.2006.10.027 | PubMed ID:17157258 | HubMed [Zhang06]
  2. Wang W, Liao P, Shen M, Chen T, Chen Y, Li Y, Lin X, Ge X, and Wang P. SCP1 regulates c-Myc stability and functions through dephosphorylating c-Myc Ser62. Oncogene. 2016 Jan 28;35(4):491-500. DOI:10.1038/onc.2015.106 | PubMed ID:25893300 | HubMed [Wang15]
  3. Sun G, Hu Z, Min Z, Yan X, Guan Z, Su H, Fu Y, Ma X, Chen YG, Zhang MQ, Tao Q, and Wu W. Small C-terminal Domain Phosphatase 3 Dephosphorylates the Linker Sites of Receptor-regulated Smads (R-Smads) to Ensure Transforming Growth Factor β (TGFβ)-mediated Germ Layer Induction in Xenopus Embryos. J Biol Chem. 2015 Jul 10;290(28):17239-49. DOI:10.1074/jbc.M115.655605 | PubMed ID:26013826 | HubMed [Sun15]
All Medline abstracts: PubMed | HubMed


Human CTDSP1, CTDSP2, and CTDSPL from NCBI Gene