Difference between revisions of "HMM PD00127"
From PhosphataseWiki
(Created page with "List of HMMs === Description === The HMM extends Pfam profile [http://pfam.xfam.org/family/PF16656.1 Pur_ac_phosph_N], which cannot detect the domain in some phosphat...") |
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=== Description === | === Description === | ||
| − | The HMM extends Pfam profile [http://pfam.xfam.org/family/PF16656.1 Pur_ac_phosph_N], which cannot detect the domain in some phosphatases, such as ''C. elegans'' ACP5 ([[Phosphatase_Sequence_CeleP014_AA]]). | + | The HMM extends Pfam profile [http://pfam.xfam.org/family/PF16656.1 Pur_ac_phosph_N], which cannot detect the domain in some phosphatases, such as ''C. elegans'' ACP5 ([[Phosphatase_Sequence_CeleP014_AA]]) and one of the Monosiga ACP5s ([[Phosphatase_Sequence_MbreP082_AA]]). |
=== How the HMM is built === | === How the HMM is built === | ||
Revision as of 17:48, 9 September 2015
Description
The HMM extends Pfam profile Pur_ac_phosph_N, which cannot detect the domain in some phosphatases, such as C. elegans ACP5 (Phosphatase_Sequence_CeleP014_AA) and one of the Monosiga ACP5s (Phosphatase_Sequence_MbreP082_AA).
How the HMM is built
We searched the Pfam domains of C. elegans ACP5 (Phosphatase_Sequence_CeleP014_AA) and human ACP5 via Pfam server. Based upon the position of Metallophos domain and the length of the linking region between Metallophos and Pur_ac_phosph_N domain, we guessed the region of 1-100 of C. elegans ACP5 (Phosphatase_Sequence_CeleP014_AA) may contain the Pur_ac_phosph_N domain.
We then PSI-BLASTed the region against NR database via NCBI BLAST server.
