HMM PD00127
From PhosphataseWiki
Description
The HMM extends Pfam profile Pur_ac_phosph_N, which cannot detect the domain in some phosphatases, such as C. elegans ACP5 (Phosphatase_Sequence_CeleP014_AA) and one of the Monosiga ACP5s (Phosphatase_Sequence_MbreP082_AA).
How the HMM is built
We searched the Pfam domains of C. elegans ACP5 (Phosphatase_Sequence_CeleP014_AA) and human ACP5 via Pfam server. Based upon the position of Metallophos domain and the length of the linking region between Metallophos and Pur_ac_phosph_N domain, we guessed the region of 1-100 of C. elegans ACP5 (Phosphatase_Sequence_CeleP014_AA) may contain the Pur_ac_phosph_N domain.
We then PSI-BLASTed the region against NR database via NCBI BLAST server.
